Office of Research, UC Riverside
Office of Research Integrity

UC IRB Reliance Registry for Studies under the UC MOU

UC Riverside is transitioning to the online UC IRB Reliance Registry for all studies in which our investigators rely on another UC campus or Lawrence Berkeley National Lab for IRB review or vice versa by means of the UC System Memorandum of Understanding (MOU). The paper version of the Notice of Intent to Rely on one UC IRB (NOITR) will be phased out and all new reliance requests, renewals and amendments will need to be submitted via the online registry.

Below is a summary of the process for Reviewing and Relying investigators. For detailed information, see:


All first-time users must register with the UC IRB Reliance Registry before they create a new reliance request.

  • If you are the Reviewing PI, go to
  • For first-time registration, click "Register" and complete the "User Registration" form. A temporary password will be sent to your email address. Use the temporary password to log in to the Registry and create a new password. Registration is now complete.

Creating a New Reliance Request

  • If you are the Reviewing PI, click the Create Request tab and disclose if your study involves Veteran Administration. Complete the information regarding your role in the study and the other required fields marked by an asterisk. Make sure to save your entries if you need to log out at any time.
  • If you are a Student Investigator for the Reviewing or Relying Campus, you must identify yourself as a Research Coordinator and your faculty sponsor as the PI. You will have access to the online reliance request but only Reviewing PIs may formally submit it via the Registry.
  • Identify your Relying PIs. The Registry will notify Relying PIs via email to register and confirm their involvement in the study. Email addresses must be entered accurately as there is no bounce-back function in the system.
  • Once all Reviewing and Relying PIs have signed up for the study via the Registry, the Reviewing PI will be able to sign a reliance request form, convert it to a PDF and submit it with their protocol application to their campus IRB for review.
  • Upon approval of the study, the Reviewing IRB will add the approval/expiration date, approved protocol, approval letter and any applicable consent forms to the study's Registry record and an automated email notice will be sent to all PIs and the Relying IRB.
  • The Relying IRB will review the documents and accept or deny the reliance via the Registry. UCR will ask that our Relying PIs provide a signed and scanned copy of our Financial Conflict of Interest Checklist (Student investigators will need to have their faculty sponsor sign as well) and a copy of the UCR Human Subjects Online Tutorial certification. If accepted, the Relying IRB will upload an Accept to Rely letter, creating an Active Reliance. All PIs and the Reviewing IRB will be notified of this decision via automated email.

Submitting Renewals and Amendments

Reviewing PIs should submit Continuing Review applications of their studies to their campus IRB, per usual. Upon approval, the Reviewing IRB will update the study's expiration date in the Registry. No Relying PI can continue work on the study if the Reviewing Campus does not submit a renewal on time.

Amendments must be submitted to the Reviewing IRB who will update any changes to the study in the Registry. The Relying PI is also responsible for informing the Reviewing PI of any necessary amendments.

Reporting Adverse/Unanticipated Events

Reports of adverse and/or unanticipated events must be submitted to the Reviewing IRB who will update any changes to the study in the Registry. The Relying PI is also responsible for informing the Reviewing PI of any adverse/unanticipated events.

For further assistance, please contact Monica Wicker at