Cayuse Proposals (S2S), formerly Cayuse 424, is a fast, easy-to-use Web application created specifically to simplify the creation, review, approval, and electronic submission of proposal applications.

For each opportunity posted on, Cayuse Proposals (S2S) downloads the appropriate forms into the Web application system, making it easy to select and apply for grants. Cayuse Proposals (S2S) supports over 98% of the opportunities posted on, allowing direct submission for grants posted by NIH, NSF, DOE, DOD, USDA, NASA, NOAA, EPA, DOE, SAMHSA, NEH, NEA, and many other federal agencies.

For more information regarding the use of Cayuse Proposals (S2S) at UCR, please contact

Highlighted Benefits

  • Cayuse Proposals (S2S) delivers an advanced validation engine that cuts development time, eliminates rework and improves first-time submission success rates to near perfect.
  • During proposal development, the system performs real-time error checking based on agency and opportunity-specific rules, validations and other business rules. You can instantly zoom in on a specific error or warning, allowing you to resolve issues and submit error-free proposals.
  • Cayuse Proposals (S2S) users can view, edit, and collaborate on proposals in any stage of development.
  • Cayuse Proposals (S2S) maintains a complete repository and history of your proposals. You can quickly sort and filter proposals, copy them, transform them to different opportunities, and delete them.

Training Modules

How do I access Cayuse Proposals (S2S)?

  • If you are a first time user of Cayuse Proposals (S2S), you will first need to establish a user account. Please contact Ms. Ursula Prins at, who will be able to link your UCR NetID to Cayuse to enable system access.
  • To access Cayuse Proposals (S2S), please click here and login using your UCR NetID and password.  (Please note that you must first be connected to GlobalProtect VPN when off-campus prior to accessing Cayuse.) 

Cayuse Proposals (S2S) Support Page and Resources: